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Tell patients that OXYCONTIN may possibly impair the chance to accomplish probably harmful routines for example driving an auto or functioning heavy equipment. Recommend individuals not to complete such jobs right until they know the way they're going to respond into the medication [see WARNINGS AND Safeguards].
OxyContin has long been made in a method that makes it tough to be misused by drug seekers. The tablet is hard to crush or crack and kinds a thick, sticky gel if blended with water which suggests it can't be injected.
A study of OXYCONTIN in patients with hepatic impairment shown larger plasma concentrations than Individuals seen at equal doses in folks with regular hepatic function [see Scientific PHARMACOLOGY].
Reducing, breaking, chewing, crushing or dissolving OXYCONTIN impairs the controlled-release shipping and delivery system and ends in the fast launch and absorption of a probably fatal dose of oxycodone.
If concomitant use is necessary, look at dosage reduction of OXYCONTIN right until secure drug results are attained. Examine patients at Recurrent intervals for respiratory depression and sedation.
In individuals having opioids for an extended time frame at high doses, ensure that a multimodal method of discomfort management, including mental health help (if needed), is in place previous to initiating an opioid analgesic taper [see DOSAGE AND ADMINISTRATION and WARNINGS AND PRECAUTIONS].
Fatal Negative effects can manifest if you utilize opioid drugs with Alcoholic beverages, or with other medications that trigger drowsiness or slow your breathing.
Take into account prescribing naloxone, based on the client’s chance variables for overdose, such as concomitant use of CNS depressants, a history of opioid use ailment, or prior opioid overdose.
Throughout unique pharmacokinetic read more experiments, average plasma oxycodone concentrations for woman topics were being read more approximately twenty five% greater than for male subjects on a body body weight-modified basis. The reason for this variation is unfamiliar [see Use In Particular Populations].
Accidental ingestion of even 1 dose of OXYCONTIN, Specifically by children, may end up in respiratory despair and Demise resulting from an overdose of oxycodone.
OXYCONTIN should be prescribed only by healthcare specialists who will be proficient about using prolonged-launch/very long-acting opioids and the way to mitigate the involved risks.
In these sufferers, mixed agonist/antagonist and partial agonist analgesics may perhaps decrease the analgesic effect and/or may perhaps precipitate withdrawal indications.
The concomitant usage of here OXYCONTIN with all cytochrome P450 3A4 inhibitors may perhaps result in an increase in oxycodone plasma concentrations, which could maximize or extend adverse drug effects and could induce most likely deadly respiratory depression.
Get hold of area condition professional licensing board or condition-controlled substances authority for info on how to forestall and detect abuse or diversion of the products.